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What is Calcium Phosphate?

Calcium phosphate is a calcium salt of phosphoric acid with a chemical formula Ca3(PO4)2. It is also known as Calcium phosphate tribasic or Tricalcium Phosphate.

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Calcium phosphate appears as a white amorphous or crystalline powder that is odourless & tasteless. It is insoluble in ethanol, acetic acid but soluble in dilute nitric acid and hydrochloric acid. It slightly dissolves in water. It is found in bones, milk, teeth, and ground.

Table of Content

Apatite is a mineral rock which is an impure & complex khung of calcium phosphate which produces tribasic calcium phosphate. An apatite is a size of phosphorite which contains calcium phosphate mixed with other compounds.

Calcium phosphates are important materials in biology, geology, industry , medicine & dentistry. Its formation, functions and applications depend on its structure , composition, solubility & stability.

Preparation of Calcium Phosphate

It can also be produced by reacting phosphoric acid (H3PO4) with solid calcium hydroxide Ca(OH)2

Ca(OH)2+H3PO4→Ca3(PO4)2+H2O (unbalanced)

3Ca(OH)2+2H3PO4→Ca3(PO4)2+6H2O (balanced equation)

Dibasic calcium phosphate can be produced in the former of these reactions by using an aqueous solution of calcium hydroxide. Monobasic calcium phosphate is obtained by adding excess phosphoric acid to lớn either a dibasic solution or a tribasic calcium phosphate solution & letting the solution to evaporate.

Properties of Calcium Phosphate – Ca3(PO4)2


Ca3(PO4)2Calcium phosphate
Molecular Weight/ Molar Mass136.06 khổng lồ 310.20 g/mol
Density (tribasic)3.14 g/cm³
Boiling PointDecomposes
Melting Point (tribasic)1670°C

Ca3P2 + H2O

Calcium phosphide reacts with water to form phosphane and calcium hydroxide. The chemical reaction is given below.

Ca3P2 + 6 H2O → 2 PH3 + 3 Ca(OH)2

Calcium Phosphate Solubility – Ca3(PO4)2

Solubility is one of the most important characteristics of calcium phosphate salts. It is solubility that defines the course of several reactions involving calcium phosphates such as absorption, precipitation, hydrolysis & phase transformation. Calcium phosphate solubility also plays a major role in biological processes including hard tissue formation & resorption as well as pathological calcification.

Calcium phosphate-based bone graft replacements (mostly tricalcium phosphate or hydroxyapatite) are bioceramics that have the greatest resemblance to bone minerals. This is what makes calcium phosphate excellent biocompatibility, biodegradability và osteoconductivity.

Calcium is a mineral found naturally in food. Calcium is essential for many normal functions of the body, in particular bone formation and maintenance. Calcium can also bind to lớn other minerals (such as phosphate) và help to lớn extract them from the body. Calcium phosphate is used lớn prevent and treat calcium deficiencies. Calcium phosphate may also be used for purposes not specified in this drug guide.

Solubility is conventionally described as the quantity of a solid that can dissolve into a unit volume of solution. With calcium phosphates, this màn chơi also varies by many orders of magnitude, including variations in pH & concentrations of acids và bases, such as HCI & NaOH. Water-soluble calcium phosphate is derived from the skeletons of vertebrate animals. Water soluble calcium phosphate is an important material for plant growth and is commonly dispersed in the soil. Calcium phosphate is insoluble in water but soluble in acids: it is used in natural farming. Calcium phosphate may dissolve slightly in CO2-containing water.

Structure of Ca3(PO4)2

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Uses of Calcium phosphate (Ca3(PO4)2)

Calcium phosphate is used as an antacid và dietary supplement in veterinary medicine.It is used in medicine as calcium replenisher.It is used as a buffer in food.It is used stabilizer in plastics.It is used in the manufacturing of milk glass.It is used in the production of fertilizers.It is used in the manufacture of luminescent materials.It is used to clarify sugar syrups.It is used in dental powders.

Occurrence of Calcium Phosphate

Calcium và phosphorus biến hóa the bulk of animal mineral nutrient requirements (to fulfill both body tissue & milk needs), hence DCPD is a popular và commonly used animal supplement. Dicalcium Phosphate Dihydrate is also of concern as it is the most soluble of barely soluble calcium phosphate crystals, making it a good choice for rock phosphate dissolution tests. The fate of DCPD in the soil is rather temporary.

Mineral phosphorus is usually applied khổng lồ soil in a water-soluble form, such as triple super phosphate or diammonium phosphate. As phosphorus dissolves a high concentration of solution P, precipitation reactions are preferred. Calcium phosphates are found in nature in many ways & are the primary minerals for the manufacture of phosphate fertilizers and for a variety of phosphorus compounds.

Health Hazards Associated with Calcium Phosphate

When the toxic doses ingested become more than 2 g/kg unusual skin sensitization occurs. Inhaling it may cause chemical pneumonitis. Calcium phosphate is used in many products in biomedicine, but also in dentistry & cosmetics. In certain situations, it is found in nanoparticle form, either on purpose or after degradation or mechanical abrasion. Possible issues refer khổng lồ the biological impact of these nanoparticles.

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A thorough literature review shows that calcium phosphate nanoparticles, as such, bởi vì not have inherent toxicity, but may lead lớn an increase in intracellular calcium concentration following endosomal uptake và lysosomal degradation. However, cells are able to lớn remove calcium from the cytoplasm within a few hours, unless very high doses of calcium phosphate are used.

The cytotoxicity observed in some cell culture studies , especially for unfunctionalized particles, is likely due lớn particle agglomeration and subsequent sedimentation on the cell layer, leading to lớn a very high local concentration of particles, high absorption of particles, và subsequent cell death.

Calcium phosphate nanoparticles can reach the bloodstream by inhalation, but no harmful effects have been observed with the exception of extended exposure to lớn high particle doses. Calcium phosphate nanoparticles within the body toàn thân do not pose a risk because they are normally resorbed & destroyed by osteoclasts & macrophages.
It can be used khổng lồ treat disorders caused by low levels of calcium such as bone loss (osteoporosis), weak bones (osteomalacia / rickets), reduced parathyroid gland function (hypoparathyroidism), và some muscle disease (latent tetanus).


Calcium can make such drugs more difficult for your body toàn thân to absorb. Calcium phosphate functions better when it’s taken with food. And ensure that you can take calcium phosphate safely, notify your doctor if you have any of the following conditions: a history of kidney stones.


Method of producing calcium phosphate fertilizer from a calcium-containing material, reactive with diluted phosphoric acid to create calcium phosphate fertilizer, calcium silicate & diluted phosphoric acid consisting of mixing the fine calcium-containing material with diluted phosphoric acid containing by weight of H3PO4 at least 30 khổng lồ 40 per cent.


Calcium is important for many normal body functions, especially bone formation and maintenance. Also, calcium can bind khổng lồ other minerals (such as phosphate), và help remove them from the body. Calcium phosphate is used to lớn avoid calcium shortages, và to treat them.


Calcium is important for many normal toàn thân functions, especially bone formation and maintenance. Also, calcium can bind to other minerals (such as phosphate), & help remove them from the body. Calcium phosphate is used khổng lồ avoid calcium shortages, và to treat them.


Side effects of calcium phosphate1. Nausea and/or vomiting2. Reduced appetite3. Constipation,4. Dry mouth or decreased hunger5. Increases sweat.


Calcium is necessary for many normal functions of the body, in particular bone formation & maintenance. Calcium can also bind to lớn other minerals (such as phosphate) and help to extract them from the body. Calcium phosphate is used lớn avoid và cure calcium deficiency.


Calcium carbonate is typically the most constipating ingredient, but provides the highest amount of calcium và is the least expensive. Calcium phosphate does not cause gas or constipation, but is more volatile than calcium carbonate.


Calcium carbonate is generally the most constipating supplement, but contains the highest amount of calcium và is the least expensive. Calcium phosphate does not cause gas or constipation, but is more costly than calcium carbonate.


Calcium carbonate và calcium citrate are the optimal supplement forms. Calcium carbonate should be taken with food because it requires stomach acid to dissolve & absorb. Calcium carbonate has the most calcium per pill (40 per cent) so fewer pills are needed.

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Calcium carbonate và calcium citrate are the two most widely used calcium products. Calcium carbonate supplements dissolve better in an acidic environment, so they should be taken with a meal. Calcium citrate supplements may be taken at any time because they do not require acid lớn dissolve.